1 thought on “Related review of intestinal flora and drug efficacy”

  1. Nat Rev Gastro Hepa [IF: 16.99]
    ① The intestinal flora regulates the response to chemotherapy drugs by promoting efficacy, removing and damage to anti -cancer effects and reducing toxicity; ② intestinal bacteria and chemotherapy drugs (5 5 -Thematic immunotherapy such as Fluoridine, cyclopensicide, Ilidekang, Osarin, Gascotabin, Aminothaate), Anti-PD-L1, and anti-CTLA-4 are closely related; Position (T), immunomotive regulation (i), metabolic (m), enzyme degradation (E), reduced diversity and ecological changes (R); ④ intestinal flora will occupy an important position in individualized therapy strategies, which is to improve the improvement. Chemotherapy efficacy and reduce good targets of chemotherapy drugs.

    gut molation of efficacy and toxicity.
    doi: 10.1038/nRGastro.2017.20/2017-0308 review
    n nat med [IF: 32.62]
    ① Intestinal flora disorders promote the development of intestinal cancer such as colorectal cancer, which is related to the deterioration of liver and breast cancer; ② When using immunoaged examination point inhibitors, specific intestinal flora can enhance systemic immune and intra -intimonia in tumor. Infiltration, but the types of flora in various experiments are very different; ③ tumor treatment such as chemotherapy and radiotherapy causes degradation of the flora, and the flora can affect the toxicity of tumor treatment; ④ The fungal flora can change the structure of the drug and activate the cancer cells Obtain drug resistance and regulate the micro -environment of tumor; ⑤ feces transplantation, probiotic/probiotic element supplement, diet intervention, targeted tumor flora, etc., may be used to regulate the flora in cancer treatment.

    the, a cancer, and a cancer therapy.
    doi: 10.1038/s41591-019-0377-7/2019-0306 review
    n Lancet Oncol [IF: 36.42]
    ① specific microbes and flora metabolites through various mechanisms can cause or regulate the occurrence of cancer; ② The regulation of the intestinal flora to the host's immune system will affect anti -cancer immunity, and the disorders of the flora may increase the risk of cancer; ③ The symbiotic flora affects the efficacy and toxicity of immunotherapy point blocking agent, stem cell transplantation, pad/chemotherapy and cell therapy; ④ fungus can be used as biomarkers for cancer treatment, but it is necessary to consider various biological, environmental, and social influence factors ; ⑤ Tung fungus transplantation, probiotics, dietary intervention and probe elements are expected to improve the efficacy of anti -cancer; ⑥ further research requires standardization of experiments and testing technologies, and establish more reliable experimental models.

    molating the to impnse in Cancer
    doi: 10.1016/s1470-2045 (18) 30952-5/2019-02-12 Review
    N Nature Review [if : 31.85]
    ① In the clinical model, the response to the host of the host can be improved by regulating the intestinal flora; Protonous cells die and promote anti -tumor immunity. PAMP activates the immune system and inflammatory response through TLR, metabolic products inhibit tumor cell proliferation and promote tumor apoptosis or autoplapse; Metabolic products have a negative impact on the prognosis of cancer; ⑤ can regulate the flora of cancer patients through means of fecal transplantation, antibiotics, probiotics/probiotics, drugs, calorie restrictions.

    effects of the and its proctor.
    doi: 10.1038/nrmicro.2017.44/20170522 Review
    n nature review [IF: 31.85]
    ① the more More research and focusing on how the flora (especially the intestinal flora) provides micro -environment for the host system to promote or prevent tumor production; The risk factors of tumor can directly affect the flora; ③ the widespread impact of the flora in cancer and the opposite role can help depict the complex and contradictory relationship between microorganisms and hosts, and may be conducive to the development of effective therapy; ④ have already already Many empirical evidence shows that the flora can directly affect the toxicity and effectiveness of anticancer drugs, and the therapy based on microorganisms has the potential to treat tumors.

    and: the.
    doi: 10.1038/.2017.8/20170222 review

    Cancer letter [IF: 6.49]
    Play a key role in the disease, which can regulate the host's immune system locally and systematically, and the immune system can change the intestinal flora to varying degrees; Or the immune examination point inhibitors of PD-L1 and CTLA-4; ③ Although the intestinal flora has potential in terms of immunotherapy, there are still some challenges, including the choice of the best septic flora transplantation (FMT) supply; ④ Other factors such as diet, sleep cycle, exercise, and drug can regulate intestinal flora. These parameters may also be related to the efficacy of immunothe check point inhibitors and other immunotherapy.

    gut and a car.
    doi: 10.1016/j.canlet.2019.01.015 review

    cancer cell [IF: 22.84]
    ① second -generation sequencing Research on the research of the flora-host immune interaction with tools such as sterile mice; ② Intestinal flora is closely related to cancer immunotherapy: some microorganisms can induce TREG and marrow-like inhibitory cells to promote immunosuppressive, weaken anti-tumor immunity, and while Others can stimulate antitumor T cells to respond by increasing antigenicity, agent, and activation of the side; ③ These regulatory functions depend on live bacteria, microbial/pathogen -related molecular patterns, flora metabolites, host cytokines and host cytokines and host cytokines and host cytokines and lobby cytotrans Immune cells and other messengers; ④ In the future, antibiotics should be considered in the future, and the formation of fungus composition/function should be considered to improve immunotherapy, and developing flora is used as a prognostic mark.

    the influice of the gut on carncer, Immunity, and Cancer.
    DOI: 10.1186/S40425-019-0574-4 Review
    n science [41.06]
    ① The flora can produce toxic/carcinogenic metabolic products, or directly or indirectly regulate the effects of tumor, progress, and treatment by causing inflammation or immunosuppressiveness; The curative effect, some bacteria can metabolize anti -cancer drugs to promote tumor chemotherapy tolerance, the diversity of flora and the abundance of specific bacteria (such as bisidobacterium, AKK bacteria) also affects the efficacy of anti -tumor; ③ flora intervention may become antitumor The therapy can be transplanted by fecal bacteria or can improve tumor immunotherapy; ④ Considering: how to choose a supply body, potential pathogenic bacteria transmission, appropriate sample conditions and storage, the number of septic bacteria transplantation, bacterial combination types, etc.

    the in Cancer: Tools and.
    DOI: 10.1126/Science.aar6918 Review

    [IF: 9.13] n ① Intestinal bacteria and tumors Bacteria can participate in regulating the effectiveness and toxicity of the drug, promote or weaken the anti-cancer effect and toxic side effects of a variety of chemotherapy drugs; /PD-1 immunotherapy, inhibit the anti-CTLA-4-induced colitis; ③ These therapies also in turn affect the intestinal flora. Chemotherapy can trigger flora dysfunction, cause excessive growth of pathogenic bacteria, and cause adverse side effects; ④ ④ Probiotics/dollars, synthetic preparations, bacterial active products, antibiotics and other flora -based intervention strategies are used to improve curative effects, reduce side effects, or help anti -cancer treatment.

    : The drag-in therabies.
    doi: 10.1186/s40168-018-0483-7 Review

    nature review [IF: 42.78]
    ① The influence of microbial groups to maintain the physiological function of the stability of the barrier to regulate metabolism, hematopoietic, inflammation, and other functions from local maintenance. Microbial groups also participated in the beginning, development and dissemination of cancer in the epithelial barrier and sterile tissue; ② intestinal microbial group regulating the response to cancer treatment and the susceptibility to toxic side effects.

    : a key of a cancer therapy.
    doi: 10.1038/nrc.2017.13. Review

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